Small Molecule APIs

Small Molecules

Small Molecule API Services

Over half of all marketed drugs are chiral, with most utilizing a single, therapeutically active enantiomer. At Sinopep, our scientists have spent over two decades mastering the large-scale, stereoselective synthesis of complex intermediates and APIs with multiple chiral centers. Our Asymmetric Synthesis Platform offers a comprehensive, one-stop solution for integrating chirality through biocatalysis, asymmetric hydrogenation and reductions, enantioselective coupling reactions, and chiral auxiliary-assisted methodologies.

To further enhance efficiency and safety, our Continuous Flow Chemistry Platform provides a compact, scalable, and economically viable alternative to traditional batch processing—especially when handling energetic reagents, unstable intermediates, or temperature-sensitive reactions. We support projects from pre-clinical to commercial scale, including non-GMP and GMP production. A key capability is continuous photochemistry, where precisely tuned light sources (UV to visible) drive complex transformations—such as pericyclic and single-electron transfer reactions—that are often difficult to achieve in batch reactors.

Small Molecule API Pipeline

  • Agomelatine
  • Atorvastatin Calcium
  • Epalrestat
  • Fulvestrant
  • Oseltamivir Phosphate
  • Sodium Picosulfate
  • Alogliptin Benzoate*
  • Roxadustat*
  • Sulindac
  • Ezetimibe
  • Risdiplam*
  • Baloxavir marboxil*
  • Elacestrant dihydrochloride*
  • Dydrogesterone
  • Elacestrant*
  • Orforglipron*
  • Rimegepant*
  • Ubrogepant*