Publications & Citations
Publications
Publications and Citations
For over two decades, Sinopep has advanced the research of leading pharmaceutical companies through our expertise in chemical synthesis and molecular design.
Multi-receptor agonist peptides represent one of the fastest-growing frontiers in metabolic disease therapeutics. Molecules such as amycretin, a dual GLP-1 and amylin receptor agonist, combine two...
Oral delivery of semaglutide is limited by low membrane permeability and gastrointestinal degradation, restricting unassisted bioavailability to well below one percent, a barrier Rybelsus® overcomes...
This paper describes a reagent-quenching strategy in which a Brønsted acid compound is introduced during the post-deprotection wash to chemically neutralize residual piperidine in situ, converting it...
Non-canonical amino acids present a fundamentally different supply challenge compared to proteinogenic residues. Standard amino acid suppliers operate at high volume for commodity materials; NCAA...
Macrocyclic peptides achieve therapeutic efficacy through precisely engineered molecular architectures that simultaneously optimize target binding, metabolic stability, and membrane permeability. The...
Conventional oxidation methods typically demand extreme dilution (<0.1–1 mg/mL) to favor intramolecular cyclization and suppress intermolecular side reactions. Sinopep has developed a methodology...
Li, S.; Jiao, J.; Meng, S.; Zhao, C.; Wu, J. Selective Ag⁺ Sensing and Cellular Imaging Based on Hydrophilic Modulated Peptide Probe. Luminescence 2026, 41, e70397...
Gothard, Chris M., and James S. Nowick. The Journal of Organic Chemistry 75.6 (2009): 1822-1830...
Wang, Peng, Mengying Jia, Yi Ren, Shiyi Xiong, Shiyang Li, and Chengqing Zhao. Available at SSRN 5358837...
