Whitepapers
Company Articles and Whitepapers
Sinopep provides whitepapers and articles on a wide range of topics, including case studies, development and manufacturing services, and technical insights into peptide and oligonucleotide chemistry.
Multi-receptor agonist peptides represent one of the fastest-growing frontiers in metabolic disease therapeutics. Molecules such as amycretin, a dual GLP-1 and amylin receptor agonist, combine two...
Oral delivery of semaglutide is limited by low membrane permeability and gastrointestinal degradation, restricting unassisted bioavailability to well below one percent, a barrier Rybelsus® overcomes...
This paper describes a reagent-quenching strategy in which a Brønsted acid compound is introduced during the post-deprotection wash to chemically neutralize residual piperidine in situ, converting it...
Non-canonical amino acids present a fundamentally different supply challenge compared to proteinogenic residues. Standard amino acid suppliers operate at high volume for commodity materials; NCAA...
Sinopep is a leading CDMO specializing in the development and GMP manufacturing of peptide, oligonucleotide, and small molecule NCEs. With the rapidly expanding landscape of peptide therapeutics, we...
Sinopep specializes in the development and cGMP manufacturing of high-quality peptide, oligonucleotide, and small molecule active pharmaceutical ingredients (APIs) intended exclusively for further...
Macrocyclic peptides achieve therapeutic efficacy through precisely engineered molecular architectures that simultaneously optimize target binding, metabolic stability, and membrane permeability. The...
Conventional oxidation methods typically demand extreme dilution (<0.1–1 mg/mL) to favor intramolecular cyclization and suppress intermolecular side reactions. Sinopep has developed a methodology...
Li, S.; Jiao, J.; Meng, S.; Zhao, C.; Wu, J. Selective Ag⁺ Sensing and Cellular Imaging Based on Hydrophilic Modulated Peptide Probe. Luminescence 2026, 41, e70397...
